The perform of SIK1 in tumorigenesis. SIK1 is often a tumor suppressor gene, which performs a vital regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 can also encourage c… Read More